[HTML][HTML] Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen
YP Han, L Zhou, J Wang, S Xiong, WL Garner… - Journal of Biological …, 2004 - ASBMB
Located within the perisinusoidal space and surrounded by extracellular matrix, hepatic
stellate cells (HSC) undergo phenotypic trans-differentiation called" myofibroblastic
activation" in liver fibrogenesis. This study investigated the regulation of interleukin-1 (IL-1α)
on expression of matrix metalloproteinases (MMPs) by HSC grown in three-dimensional
extracellular matrix and the role of MMPs in HSC activation. To recapitulate the in vivo"
quiescent" state of HSC, the isolated rat HSC were grown in three-dimensional Matrigel or …
stellate cells (HSC) undergo phenotypic trans-differentiation called" myofibroblastic
activation" in liver fibrogenesis. This study investigated the regulation of interleukin-1 (IL-1α)
on expression of matrix metalloproteinases (MMPs) by HSC grown in three-dimensional
extracellular matrix and the role of MMPs in HSC activation. To recapitulate the in vivo"
quiescent" state of HSC, the isolated rat HSC were grown in three-dimensional Matrigel or …