Progressive liver fibrosis is the main cause of organ failure in chronic liver diseases of any
aetiology. Fibrosis develops with different spatial patterns and is a consequence of different
prevalent mechanisms according to the diverse causes of parenchymal damage. Indeed,
fibrosis, observed as a consequence of chronic viral infection is initially concentrated within
and around the portal tract, while fibrosis secondary to toxic/metabolic damage is located
mainly in the centrolobular areas. In addition, it is increasingly evident that different cell …