Antiepileptic drug–induced bone loss in young male patients who have seizures

DL Andress, J Ozuna, D Tirschwell, L Grande… - Archives of …, 2002 - jamanetwork.com
Background Long-term antiepileptic drug (AED) therapy is a known risk factor for bone loss
and fractures. Vitamin D deficiency is frequently cited as a cause for bone loss in patients
who have seizures. Objective To determine whether men who have seizures, but who are
otherwise healthy, suffer substantial bone loss in the hip while taking AEDs. Patients and
Methods We prospectively examined femoral neck bone mineral density (BMD) by dual-
energy x-ray absorptiometry in 81 consecutive men, aged between 25 and 54 years old …