[HTML][HTML] Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokines
A Janowska-Wieczorek, LA Marquez… - Experimental …, 2000 - Elsevier
OBJECTIVE: As stromal cell–derived factor-1 (SDF-1), macrophage inflammatory protein-1α
(MIP-1α), and interleukin-8 (IL-8) are implicated in the homing and mobilization of human
hematopoietic progenitors (HPC), we hypothesized that these chemokines mediate the
migration of HPC across subendothelial basement membranes by regulating production of
matrix metalloproteinases (MMPs) and their natural tissue inhibitors (TIMPs). MATERIALS
AND METHODS: Assays for migration across reconstituted basement membrane (Matrigel) …
(MIP-1α), and interleukin-8 (IL-8) are implicated in the homing and mobilization of human
hematopoietic progenitors (HPC), we hypothesized that these chemokines mediate the
migration of HPC across subendothelial basement membranes by regulating production of
matrix metalloproteinases (MMPs) and their natural tissue inhibitors (TIMPs). MATERIALS
AND METHODS: Assays for migration across reconstituted basement membrane (Matrigel) …