[HTML][HTML] Ceramide directly activates protein kinase C ζ to regulate a stress-activated protein kinase signaling complex
NA Bourbon, J Yun, M Kester - Journal of Biological Chemistry, 2000 - ASBMB
We have previously shown that interleukin 1 (IL-1)-receptor-generated ceramide induces
growth arrest in smooth muscle pericytes by activating an upstream kinase in the stress-
activated protein kinase (SAPK) cascade. We now report the mechanism by which ceramide
activates the SAPK signaling pathway in human embryonic kidney cells (HEK-293). We
demonstrate that ceramide activation of protein kinase C ζ (PKCζ) mediates SAPK signal
complex formation and subsequent growth suppression. Ceramide directly activates both …
growth arrest in smooth muscle pericytes by activating an upstream kinase in the stress-
activated protein kinase (SAPK) cascade. We now report the mechanism by which ceramide
activates the SAPK signaling pathway in human embryonic kidney cells (HEK-293). We
demonstrate that ceramide activation of protein kinase C ζ (PKCζ) mediates SAPK signal
complex formation and subsequent growth suppression. Ceramide directly activates both …