[HTML][HTML] Chylomicron metabolism in an animal model for hyperlipoproteinemia type I
R Savonen, K Nordstoga, B Christophersen… - Journal of lipid …, 1999 - ASBMB
Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of
LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In
normal mink, lymph chylomicrons from rats given [3 H] retinol (incorporated into retinyl
esters, providing a core label) and [14 C] oleic acid (incorporated mainly in triglycerides
(TG)) were rapidly cleared from the circulation. In the homozygous mink, clearance was
much retarded. The ratio of TG to core label in plasma did not decrease and much less [14 …
LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In
normal mink, lymph chylomicrons from rats given [3 H] retinol (incorporated into retinyl
esters, providing a core label) and [14 C] oleic acid (incorporated mainly in triglycerides
(TG)) were rapidly cleared from the circulation. In the homozygous mink, clearance was
much retarded. The ratio of TG to core label in plasma did not decrease and much less [14 …