Aggregated immunoglobulin and Fc fragment of IgG induce IL-6 release from human monocytes
ZD Ling, HJ Ziltener, BT Webb, DS Matheson - Cellular immunology, 1990 - Elsevier
The Fc fragment of immunoglobulin (Ig) has been shown to play an important role in the
regulation of humoral immunity, cellular immunity, lymphocyte and monocyte activation, and
immune mediator secretion. We wished to determine if Ig or Fc fragments would induce IL-6
production from monocytes. Incubation of monocytes purified from human peripheral blood
mononuclear cells with aggregated Ig or Fc fragments of Ig induced interleukin-6 (IL-6)
activity in the supernatants. Monomeric Ig taken from an intravenous preparation of Ig, from …
regulation of humoral immunity, cellular immunity, lymphocyte and monocyte activation, and
immune mediator secretion. We wished to determine if Ig or Fc fragments would induce IL-6
production from monocytes. Incubation of monocytes purified from human peripheral blood
mononuclear cells with aggregated Ig or Fc fragments of Ig induced interleukin-6 (IL-6)
activity in the supernatants. Monomeric Ig taken from an intravenous preparation of Ig, from …