Comparative analysis of anti-hepatitis C virus activity and gene expression mediated by alpha, beta, and gamma interferons
IW Cheney, VCH Lai, W Zhong, T Brodhag… - Journal of …, 2002 - Am Soc Microbiol
IW Cheney, VCH Lai, W Zhong, T Brodhag, S Dempsey, C Lim, Z Hong, JYN Lau, RC Tam
Journal of virology, 2002•Am Soc MicrobiolABSTRACT A direct comparison of the inhibitory effects of alpha, beta, and gamma
interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma
cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral
mechanisms were suggested following observations of striking differences between IFN-γ
and IFN-α/β with respect to strength and durability of the antiviral response and the
magnitude and pattern of IFN-mediated gene expression.
interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma
cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral
mechanisms were suggested following observations of striking differences between IFN-γ
and IFN-α/β with respect to strength and durability of the antiviral response and the
magnitude and pattern of IFN-mediated gene expression.
Abstract
A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-γ and IFN-α/β with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.
American Society for Microbiology