Fatal Mycobacterium bovis BCG infection in TNF-LT-α-deficient mice
M Jacobs, N Brown, N Allie, B Ryffel - Clinical immunology, 2000 - Elsevier
Neutralization of TNF or disruption of TNF-R1 leads to fatal Mycobacterium bovis BCG
infection. Here we used TNF-LT-α-deficient mice to test whether a complete disruption of
TNF and LT-α reduces further host resistance to BCG infection. The bacterial burden
especially in the lungs of TNF-LT-α-deficient mice was significantly increased and the mice
succumbed to infection between 8 and 10 weeks. In the absence of TNF-LT-α the
granulomatous response was severely impaired and delayed. The cells in the granulomas …
infection. Here we used TNF-LT-α-deficient mice to test whether a complete disruption of
TNF and LT-α reduces further host resistance to BCG infection. The bacterial burden
especially in the lungs of TNF-LT-α-deficient mice was significantly increased and the mice
succumbed to infection between 8 and 10 weeks. In the absence of TNF-LT-α the
granulomatous response was severely impaired and delayed. The cells in the granulomas …