[HTML][HTML] N ε-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate …
T Kislinger, C Fu, B Huber, W Qu, A Taguchi… - Journal of Biological …, 1999 - ASBMB
Recent studies suggested that interruption of the interaction of advanced glycation end
products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by
administration of the soluble, extracellular ligand-binding domain of RAGE, reversed
vascular hyperpermeability and suppressed accelerated atherosclerosis in diabetic rodents.
Since the precise molecular target of soluble RAGE in those settings was not elucidated, we
tested the hypothesis that predominant specific AGEs within the tissues in disorders such as …
products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by
administration of the soluble, extracellular ligand-binding domain of RAGE, reversed
vascular hyperpermeability and suppressed accelerated atherosclerosis in diabetic rodents.
Since the precise molecular target of soluble RAGE in those settings was not elucidated, we
tested the hypothesis that predominant specific AGEs within the tissues in disorders such as …