[HTML][HTML] Angiostatin inhibits bone metastasis formation in nude mice through a direct anti-osteoclastic activity
O Peyruchaud, CM Serre, R NicAmhlaoibh… - Journal of Biological …, 2003 - ASBMB
Bone is a very common metastatic site for breast cancer. In bone metastasis, there is a
vicious circle wherein bone-residing metastatic cells stimulate osteoclast-mediated bone
resorption, and bone-derived growth factors released from resorbed bone promote tumor
growth. The contribution of tumor angiogenesis in the growth of bone metastases is,
however, unknown. By using an experimental model of bone metastasis caused by MDA-MB-
231/B02 breast cancer cells that quite closely mimics the conditions likely to occur in …
vicious circle wherein bone-residing metastatic cells stimulate osteoclast-mediated bone
resorption, and bone-derived growth factors released from resorbed bone promote tumor
growth. The contribution of tumor angiogenesis in the growth of bone metastases is,
however, unknown. By using an experimental model of bone metastasis caused by MDA-MB-
231/B02 breast cancer cells that quite closely mimics the conditions likely to occur in …