A potential role for lysophosphatidic acid (LPA) in human oncogenesis was first suggested
by the observation that LPA is present at elevated levels in ascites of ovarian cancer
patients. In the current study, we demonstrated that LPA is a potent inducer of interleukin-6
(IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. Both IL-6 and IL-8 have
been implicated in ovarian cancer progression. We characterized the IL-8 gene promoter to
ascertain the transcriptional mechanism underlying LPA-induced expression of these …