Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.
Y Geng, RA Weinberg - Proceedings of the National …, 1993 - National Acad Sciences
Y Geng, RA Weinberg
Proceedings of the National Academy of Sciences, 1993•National Acad SciencesTransforming growth factor beta 1 (TGF-beta 1) is a potent growth-inhibitory polypeptide.
The mechanism of TGF-beta 1 inhibition has been related to its ability to prevent the
hyperphosphorylation of retinoblastoma protein (pRb). Several lines of evidence have
suggested that cell cycle-regulated protein kinases are responsible for the
hyperphosphorylation of pRb. We demonstrate here that TGF-beta 1 has profound effects on
the expression of genes encoding certain G1 cyclins and their associated kinases, which …
The mechanism of TGF-beta 1 inhibition has been related to its ability to prevent the
hyperphosphorylation of retinoblastoma protein (pRb). Several lines of evidence have
suggested that cell cycle-regulated protein kinases are responsible for the
hyperphosphorylation of pRb. We demonstrate here that TGF-beta 1 has profound effects on
the expression of genes encoding certain G1 cyclins and their associated kinases, which …
Transforming growth factor beta 1 (TGF-beta 1) is a potent growth-inhibitory polypeptide. The mechanism of TGF-beta 1 inhibition has been related to its ability to prevent the hyperphosphorylation of retinoblastoma protein (pRb). Several lines of evidence have suggested that cell cycle-regulated protein kinases are responsible for the hyperphosphorylation of pRb. We demonstrate here that TGF-beta 1 has profound effects on the expression of genes encoding certain G1 cyclins and their associated kinases, which provides one explanation of TGF-beta 1 effects on pRb hyperphosphorylation. These results also suggest that the growth-inhibitory effects of TGF-beta 1 in many cells are attributable to its effects on the cell cycle apparatus involved in programming G1 transit.
National Acad Sciences