Introduction 2.1. Endothelial cells in vascular biology 2.2. Signaling through FAK and Pyk2 3. Endothelial Cell Turnover 3.1. FAK regulation of endothelial cell proliferation 3.2. FAK signaling in endothelial cell apoptosis 4. Endothelial Cell Migration and Angiogenesis 4.1. Regulation of angiogenesis 4.2. FAK signaling in growth factor-induced angiogenesis 4.3. FAK in endothelial cell invasion 4.4. Pyk2 signaling in angiogenesis 5. Regulation of Endothelial Barrier Function 5.1. Modulating vascular permeability 5.2. Endothelial contractility and FAK signaling 5.3. Endothelial cell interactions with inflammatory cells 6. Hemodynamic Force Transduction 6.1. Endothelial cell mechanotransduction 6.2. Mechanotransduction through FAK 6.3. Pyk2 in mechanical signaling 7. Summary and Perspective 8. Acknowledgement 9. References