[HTML][HTML] Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1. 0 cells: involvement of phosphatidylinositol 3-kinase …
MT Lin, RC Lee, PC Yang, FM Ho, ML Kuo - Journal of Biological Chemistry, 2001 - ASBMB
Cyclooxygenase 2 (COX-2) has been reported to be commonly expressed in advanced
stages of human lung adenocarcinoma. In this study, the COX-2 constitutive expression
vector was transfected into a human lung adenocarcinoma cell line CL1. 0 and several
clones were obtained which stably expressed COX-2. These COX-2-overexpressed clones
demonstrated remarkable resistance to apoptosis induced by Ultraviolet B (UVB) irradiation,
vinblastine B (VBL) cell lymphoma-2 (Bcl-2), or other anti-cancer drugs. To understand how …
stages of human lung adenocarcinoma. In this study, the COX-2 constitutive expression
vector was transfected into a human lung adenocarcinoma cell line CL1. 0 and several
clones were obtained which stably expressed COX-2. These COX-2-overexpressed clones
demonstrated remarkable resistance to apoptosis induced by Ultraviolet B (UVB) irradiation,
vinblastine B (VBL) cell lymphoma-2 (Bcl-2), or other anti-cancer drugs. To understand how …