Non-MHC-restricted cytotoxic cells: their roles in the control and treatment of leukaemias.
MW Lowdell, L Lamb, C Hoyle… - British journal of …, 2001 - search.ebscohost.com
MW Lowdell, L Lamb, C Hoyle, A Velardi, HG Prentice
British journal of haematology, 2001•search.ebscohost.comReview Page 1 British Journal of Haematology, 2001, 114, 11±24 Review NON-MHC-RESTRICTED
CYTOTOXIC CELLS: THEIR ROLES IN THE CONTROL AND TREATMENT OF LEUKAEMIAS
The role of T lymphocytes in the MHC-restricted control and eradication of leukaemia after
allogeneic bone marrow transplantation is established, but there is increasing evidence
that the non-MHC-restricted cytotoxic lymphocytes have the capacity to lyse allogeneic or,
in some cases, autologous leukaemic blasts. Recently, the field of tumour immunotherapy …
CYTOTOXIC CELLS: THEIR ROLES IN THE CONTROL AND TREATMENT OF LEUKAEMIAS
The role of T lymphocytes in the MHC-restricted control and eradication of leukaemia after
allogeneic bone marrow transplantation is established, but there is increasing evidence
that the non-MHC-restricted cytotoxic lymphocytes have the capacity to lyse allogeneic or,
in some cases, autologous leukaemic blasts. Recently, the field of tumour immunotherapy …
Abstract
Examines the role of non-major histocompatibility complex-restricted cytotoxic cells in the control and treatment of leukemia. Characteristics of gamma delta T cells; Physiological effect of natural killer (NK) T cells; Role of NK cells.
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