Examining potential drug therapies for muscular dystrophy utilising the dy/dy mouse: I. Clenbuterol
A Hayes, DA Williams - Journal of the neurological sciences, 1998 - Elsevier
As a potent promoter of muscle growth, clenbuterol has been proposed as a treatment for
muscle wasting diseases. Thus, the effects of clenbuterol on dystrophic skeletal muscle was
examined. Male dystrophic (dy/dy) mice aged 4–5 weeks were treated with clenbuterol for 3
weeks, and the isometric contractile, fatigue and histochemical properties of the slow-twitch
soleus and fast-twitch plantaris muscles measured. Muscles of dystrophic animals produced
lower forces, contracted more slowly and exhibited greater fatigue resistance than age …
muscle wasting diseases. Thus, the effects of clenbuterol on dystrophic skeletal muscle was
examined. Male dystrophic (dy/dy) mice aged 4–5 weeks were treated with clenbuterol for 3
weeks, and the isometric contractile, fatigue and histochemical properties of the slow-twitch
soleus and fast-twitch plantaris muscles measured. Muscles of dystrophic animals produced
lower forces, contracted more slowly and exhibited greater fatigue resistance than age …