Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats
MS Gevaerd, RN Takahashi, R Silveira… - Brain Research …, 2001 - Elsevier
The present study was carried out to test the possible effects of caffeine in improving the
memory deficits observed in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyrindine (MPTP)-
lesioned rats, an animal model of early stage Parkinson's disease. Caffeine at the doses of
0.1–0.3 mg/kg (intraperitoneal) reversed the impairing effect of the administration of MPTP (1
μmol/side) into the substantia nigra, compact part, of rats on the avoidance scores in the
training and test sessions of a two-way active avoidance task. This effect was not due to a …
memory deficits observed in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyrindine (MPTP)-
lesioned rats, an animal model of early stage Parkinson's disease. Caffeine at the doses of
0.1–0.3 mg/kg (intraperitoneal) reversed the impairing effect of the administration of MPTP (1
μmol/side) into the substantia nigra, compact part, of rats on the avoidance scores in the
training and test sessions of a two-way active avoidance task. This effect was not due to a …