Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments
WK Cullen, YH Suh, R Anwyl, MJ Rowan - Neuroreport, 1997 - journals.lww.com
THE effects of β-amyloid precursor protein (β-APP) fragments on plasticity of glutamtatergic
synaptic transmission were examined in the hippocampus of urethane anaesthetized rats.
Icv injection of β-amyloid (Aβ) 1–40 and 1–42 and the C-terminal fragment CT105 greatly
shortened the duration of high frequency stimulation-induced long-term potentiation (LTP) of
field excitatory postsynaptic potentials in the CA1 area. Whereas in vehicle injected animals
LTP was stable over a 5 h recording period, doses of these peptides (Aβ1–40, 0.4 and 3.5 …
synaptic transmission were examined in the hippocampus of urethane anaesthetized rats.
Icv injection of β-amyloid (Aβ) 1–40 and 1–42 and the C-terminal fragment CT105 greatly
shortened the duration of high frequency stimulation-induced long-term potentiation (LTP) of
field excitatory postsynaptic potentials in the CA1 area. Whereas in vehicle injected animals
LTP was stable over a 5 h recording period, doses of these peptides (Aβ1–40, 0.4 and 3.5 …