BAFF AND APRIL: a tutorial on B cell survival
F Mackay, P Schneider, P Rennert… - Annual review of …, 2003 - annualreviews.org
F Mackay, P Schneider, P Rennert, J Browning
Annual review of immunology, 2003•annualreviews.orgBAFF, a member of the TNF family, is a fundamental survival factor for transitional and
mature B cells. BAFF overexpression leads to an expanded B cell compartment and
autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of
autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears
to play a different biological role. The BAFF system provides not only potential insight into
the development of autoreactive B cells but a relatively simple paradigm to begin …
mature B cells. BAFF overexpression leads to an expanded B cell compartment and
autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of
autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears
to play a different biological role. The BAFF system provides not only potential insight into
the development of autoreactive B cells but a relatively simple paradigm to begin …
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
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