[HTML][HTML] Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance
P Most, A Remppis, ST Pleger, E Löffler… - Journal of Biological …, 2003 - ASBMB
S100A1, a Ca 2+-sensing protein of the EF-hand family, is most highly expressed in
myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance
myocyte contractile properties. To study the physiological consequences of S100A1 in vivo,
transgenic mice were developed with cardiac-restricted overexpression of S100A1.
Characterization of two independent transgenic mouse lines with∼ 4-fold overexpression of
S100A1 in the myocardium revealed a marked augmentation of in vivo basal cardiac …
myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance
myocyte contractile properties. To study the physiological consequences of S100A1 in vivo,
transgenic mice were developed with cardiac-restricted overexpression of S100A1.
Characterization of two independent transgenic mouse lines with∼ 4-fold overexpression of
S100A1 in the myocardium revealed a marked augmentation of in vivo basal cardiac …