[HTML][HTML] Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia
DR Laybutt, A Sharma, DC Sgroi, J Gaudet… - Journal of Biological …, 2002 - ASBMB
In models of type 2 diabetes the expression of β-cell genes is altered, but these changes
have not fully explained the impairment in β-cell function. We hypothesized that changes in
β-cell phenotype and global alterations in both carbohydrate and lipid pathways are likely to
contribute to secretory abnormalities. Therefore, expression of genes involved in
carbohydrate and lipid metabolism were analyzed in islets 4 weeks after 85–95% partial
pancreatectomy (Px) when β-cells have impaired glucose-induced insulin secretion and …
have not fully explained the impairment in β-cell function. We hypothesized that changes in
β-cell phenotype and global alterations in both carbohydrate and lipid pathways are likely to
contribute to secretory abnormalities. Therefore, expression of genes involved in
carbohydrate and lipid metabolism were analyzed in islets 4 weeks after 85–95% partial
pancreatectomy (Px) when β-cells have impaired glucose-induced insulin secretion and …