[HTML][HTML] A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors
The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid
(LPA) are ligands for the related G protein-coupled receptors S1P 1/EDG1 and LPA 1/EDG2,
respectively. We have developed a model of LPA 1 that predicts interactions between three
polar residues and LPA. One of these, glutamine 125, which is conserved in the LPA
receptor subfamily (LPA 1/EDG2, LPA 2/EDG4, and LPA 3/EDG7), hydrogen bonds with the
LPA hydroxyl group. Our previous S1P 1 study identified that the corresponding glutamate …
(LPA) are ligands for the related G protein-coupled receptors S1P 1/EDG1 and LPA 1/EDG2,
respectively. We have developed a model of LPA 1 that predicts interactions between three
polar residues and LPA. One of these, glutamine 125, which is conserved in the LPA
receptor subfamily (LPA 1/EDG2, LPA 2/EDG4, and LPA 3/EDG7), hydrogen bonds with the
LPA hydroxyl group. Our previous S1P 1 study identified that the corresponding glutamate …