[HTML][HTML] Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles

S Miura, Y Kai, M Ono, O Ezaki - Journal of Biological Chemistry, 2003 - ASBMB
Exercise training increases mitochondria and GLUT4 in skeletal muscles. Recent studies
indicate that an increased expression of the transcriptional coactivator peroxisome
proliferator-activated receptor γ coactivator 1α (PGC-1α) by exercise may promote
mitochondrial biogenesis and fatty acid oxidation. To examine whether increased PGC-1α
expression was also responsible for an increase of GLUT4 expression, transgenic mice that
overexpress PGC-1α in skeletal muscles driven by a human α-skeletal actin promoter were …