[HTML][HTML] Conformational and Biochemical Differences in the TCR· CD3 Complex of CD8+ Versus CD4+ Mature Lymphocytes Revealed in the Absence of CD3γ
DA Zapata, A Pacheco-Castro, PS Torres… - Journal of Biological …, 1999 - ASBMB
Mature CD4+ and CD8+ T lymphocytes are believed to build and express essentially
identical surface αβ T-cell receptor-CD3 (TCR· CD3) complexes. However, TCR· CD3
expression has been shown to be more impaired in CD8+ cells than in CD4+ cells when
CD3γ is absent in humans or mice. We have addressed this paradox by performing a
detailed phenotypical and biochemical analysis of the TCR· CD3 complex in human CD3γ-
deficient CD8+ and CD4+ T cells. The results indicated that the membrane TCR· CD3 …
identical surface αβ T-cell receptor-CD3 (TCR· CD3) complexes. However, TCR· CD3
expression has been shown to be more impaired in CD8+ cells than in CD4+ cells when
CD3γ is absent in humans or mice. We have addressed this paradox by performing a
detailed phenotypical and biochemical analysis of the TCR· CD3 complex in human CD3γ-
deficient CD8+ and CD4+ T cells. The results indicated that the membrane TCR· CD3 …