Pemphigus is a unique and interesting autoimmune disease, in which autoantibodies play a
major pathogenic role and cause blister formation. Several questions raised from clinical
observation in pemphigus have been answered with logic at the molecular level owing to
recent remarkable progress in research in the field of pemphigus. The clinical phenotype of
classic pemphigus, pemphigus vulgaris (PV) and pemphigus foliaceus (PF), is defined by
anti-desmoglein autoantibody profile. Sera containing anti-Dsg3 IgG alone cause mucosal …