[HTML][HTML] A perfect message: RNA surveillance and nonsense-mediated decay
MW Hentze, AE Kulozik - Cell, 1999 - cell.com
Cell, 1999•cell.com
The robustness of biological systems depends on the function of proofreading mechanisms
against operating errors. Studies in yeast and of human genetic disorders have lead the way
to a conserved surveillance mechanism that identifies faulty open reading frames (ORFs)
and eliminates “imperfect messages” that contain premature translation termination codons
(PTCs) and code for nonfunctional or even harmful polypeptides; this mechanism has been
termed nonsense-mediated mRNA decay (NMD).
against operating errors. Studies in yeast and of human genetic disorders have lead the way
to a conserved surveillance mechanism that identifies faulty open reading frames (ORFs)
and eliminates “imperfect messages” that contain premature translation termination codons
(PTCs) and code for nonfunctional or even harmful polypeptides; this mechanism has been
termed nonsense-mediated mRNA decay (NMD).
The robustness of biological systems depends on the function of proofreading mechanisms against operating errors. Studies in yeast and of human genetic disorders have lead the way to a conserved surveillance mechanism that identifies faulty open reading frames (ORFs) and eliminates “imperfect messages” that contain premature translation termination codons (PTCs) and code for nonfunctional or even harmful polypeptides; this mechanism has been termed nonsense-mediated mRNA decay (NMD).
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