[HTML][HTML] Heme positively regulates the expression of β-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells
T Tahara, J Sun, K Nakanishi, M Yamamoto… - Journal of Biological …, 2004 - ASBMB
The transcription factor Bach1 heterodimerizes with small Maf proteins to repress Maf
recognition element (MARE)-dependent gene expression. The repressor activity of Bach1 is
inhibited by the direct binding of heme. To investigate the involvement of Bach1 in the heme-
dependent regulation of the expression of the β-globin gene, mouse erythroleukemia (MEL)
cells were cultured with succinylacetone (SA), a specific inhibitor of heme biosynthesis, and
the level of β-globin mRNA was examined. A marked decrease of β-globin mRNA in SA …
recognition element (MARE)-dependent gene expression. The repressor activity of Bach1 is
inhibited by the direct binding of heme. To investigate the involvement of Bach1 in the heme-
dependent regulation of the expression of the β-globin gene, mouse erythroleukemia (MEL)
cells were cultured with succinylacetone (SA), a specific inhibitor of heme biosynthesis, and
the level of β-globin mRNA was examined. A marked decrease of β-globin mRNA in SA …