Intramembrane proteolysis controls diverse signalling pathways throughout evolution
S Urban, M Freeman - Current opinion in genetics & development, 2002 - Elsevier
S Urban, M Freeman
Current opinion in genetics & development, 2002•ElsevierRegulated intramembrane proteolysis (RIP) has recently emerged as a conserved
mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes.
Although early examples were confined to the activation of membrane-tethered transcription
factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the
emission of factors involved in intercellular communication.
mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes.
Although early examples were confined to the activation of membrane-tethered transcription
factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the
emission of factors involved in intercellular communication.
Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.
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