[HTML][HTML] The polycystic kidney disease 1 gene product mediates protein kinase C α-dependent and c-Jun N-terminal kinase-dependent activation of the transcription …
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder
that accounts for 8–10% of end stage renal disease. PKD1, one of two recently isolated
ADPKD gene products, has been implicated in cell-cell and cell-matrix interactions.
However, the signaling pathway of PKD1 remains undefined. We found that the C-terminal
226 amino acids of PKD1 transactivate an AP-1 promoter construct in human embryonic
kidney cells (293T). PKD1-induced transcription is specific for AP-1; promoter constructs …
that accounts for 8–10% of end stage renal disease. PKD1, one of two recently isolated
ADPKD gene products, has been implicated in cell-cell and cell-matrix interactions.
However, the signaling pathway of PKD1 remains undefined. We found that the C-terminal
226 amino acids of PKD1 transactivate an AP-1 promoter construct in human embryonic
kidney cells (293T). PKD1-induced transcription is specific for AP-1; promoter constructs …