[HTML][HTML] Series Introduction: Invasive growth: from development to metastasis

PM Comoglio, L Trusolino - The Journal of clinical …, 2002 - Am Soc Clin Investig
The Journal of clinical investigation, 2002Am Soc Clin Investig
The invasive growth program under physiological and pathological conditions. In both
settings, invasive growth results from analogous biological processes–cell-cell dissociation
and migration, cell multiplication, and survival–but the endpoints are different. Normal cells
exploit invasive growth to colonize new territories and build polarized three-dimensional
structures, thus forming the parenchymal architecture of several organs. Cancer cells
implement this program aberrantly to infiltrate the adjacent surroundings and form …
The invasive growth program under physiological and pathological conditions. In both settings, invasive growth results from analogous biological processes–cell-cell dissociation and migration, cell multiplication, and survival–but the endpoints are different. Normal cells exploit invasive growth to colonize new territories and build polarized three-dimensional structures, thus forming the parenchymal architecture of several organs. Cancer cells implement this program aberrantly to infiltrate the adjacent surroundings and form metastases.
The Journal of Clinical Investigation