[PDF][PDF] Human disease: calcium signaling in polycystic kidney disease
S Somlo, B Ehrlich - Current Biology, 2001 - cell.com
S Somlo, B Ehrlich
Current Biology, 2001•cell.comPolycystic kidney disease results from loss of function of either of two novel proteins,
polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is
important in kidney development, and define defects in this signaling pathway as the basis
of cyst formation in polycystic kidney disease.
polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is
important in kidney development, and define defects in this signaling pathway as the basis
of cyst formation in polycystic kidney disease.
Abstract
Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease.
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