[PDF][PDF] Mixed chimerism and transplant tolerance

M Sykes - Immunity, 2001 - cell.com
M Sykes
Immunity, 2001cell.com
Mixed Chimerism Review and Transplant Tolerance Page 1 Immunity, Vol. 14, 417–424, April,
2001, Copyright ©2001 by Cell Press Mixed Chimerism Review and Transplant Tolerance host
origin, and the antigen-presenting cells (APC) in the periphery, which are entirely of donor origin
in full chimeras. These T cells are ineffective at mounting rele- Megan Sykes* Bone Marrow
Transplantation Section Transplantation Biology Research Center Massachusetts General
Hospital/Harvard vant donor-restricted immune responses and lack host APC that could …
Background: Mixed Chimerism as an Approach cells do not participate in positive selection is controverto Tolerance Induction sial and has recently been challenged (Zinkernagel and Induction of specific immunologic tolerance to donor
cell.com