Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity
H Tighe, K Takabayashi, D Schwartz… - Journal of Allergy and …, 2000 - Elsevier
Background: Allergen immunotherapy is inconvenient and associated with the risk of
anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical
modification of allergens have not been successful because it greatly reduced their
antigenicity. Recently, immunostimulatory DNA sequences (ISS or CpG motifs) have been
shown to act as strong TH1 response–inducing adjuvants. Objective: We sought to
determine whether conjugation of ISS to the major short ragweed allergen Amb a 1 results in …
anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical
modification of allergens have not been successful because it greatly reduced their
antigenicity. Recently, immunostimulatory DNA sequences (ISS or CpG motifs) have been
shown to act as strong TH1 response–inducing adjuvants. Objective: We sought to
determine whether conjugation of ISS to the major short ragweed allergen Amb a 1 results in …