Toll-like receptor 2 as a major gene for asthma in children of European farmers
W Eder, W Klimecki, L Yu, E von Mutius… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: The finding that the prevalence of asthma and allergies is less frequent in
children raised on animal farms has led to the conjecture that exposure to microbial products
modifies immune responses. The toll-like receptors (TLRs) represent an evolutionarily
conserved family of innate immunity receptors with microbial molecules as ligands.
OBJECTIVES: We reasoned that polymorphisms in genes encoding TLRs might modulate
the protective effects observed in farming populations. METHODS: Farmers' and nonfarmers' …
children raised on animal farms has led to the conjecture that exposure to microbial products
modifies immune responses. The toll-like receptors (TLRs) represent an evolutionarily
conserved family of innate immunity receptors with microbial molecules as ligands.
OBJECTIVES: We reasoned that polymorphisms in genes encoding TLRs might modulate
the protective effects observed in farming populations. METHODS: Farmers' and nonfarmers' …