Regulatory T cells control the development of allergic disease and asthma

DT Umetsu, O Akbari, RH DeKruyff, WT Shearer… - Journal of Allergy and …, 2003 - Elsevier
The role of TH2 cells in the pathogenesis of allergy and asthma has been well described.
However, the immunologic mechanisms that downmodulate and protect against the
development of these disorders are poorly characterized. A spectrum of CD4+ T cells,
including TH1 cells, TH3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells
might play a critical role in regulating these diseases and are discussed in this review.