Circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage
HJJ Van Der Vliet, BME Von Blomberg, N Nishi… - Clinical …, 2001 - Elsevier
Natural killer T (NKT) cells have been implicated as playing an important role in regulating
immune responses. Defects in the NKT cell population were reported in animal autoimmune
disease models and in distincthuman autoimmune diseases. Here, we report that circulating
Vα24+ Vβ11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)
immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints,
regardless of disease duration or activity. Remarkably, normal circulating Vα24+ Vβ11+ NKT …
immune responses. Defects in the NKT cell population were reported in animal autoimmune
disease models and in distincthuman autoimmune diseases. Here, we report that circulating
Vα24+ Vβ11+ NKT cell numbers are decreased in a broad variety of disorders with (auto)
immune-mediated pathology, affecting the skin, bowel, central nervous system, and joints,
regardless of disease duration or activity. Remarkably, normal circulating Vα24+ Vβ11+ NKT …