CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
L Schofield, MJ McConville, D Hansen, AS Campbell… - Science, 1999 - science.org
L Schofield, MJ McConville, D Hansen, AS Campbell, B Fraser-Reid, MJ Grusby…
Science, 1999•science.orgImmunoglobulin G (IgG) responses require major histocompatibility complex (MHC)–
restricted recognition of peptide fragments by conventional CD4+ helper T cells.
Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein
antigens, however, were found to be regulated in part through CD1d-restricted recognition of
the GPI moiety by thymus-dependent, interleukin-4–producing CD4+, natural killer cell
antigen 1.1 [(NK1. 1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin …
restricted recognition of peptide fragments by conventional CD4+ helper T cells.
Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein
antigens, however, were found to be regulated in part through CD1d-restricted recognition of
the GPI moiety by thymus-dependent, interleukin-4–producing CD4+, natural killer cell
antigen 1.1 [(NK1. 1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin …
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)–restricted recognition of peptide fragments by conventional CD4+ helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4–producing CD4+, natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium andTrypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
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