α-Galactosylceramide: potential immunomodulatory activity and future application [general articles]
Y Hayakawa, DI Godfrey… - Current medicinal …, 2004 - ingentaconnect.com
Y Hayakawa, DI Godfrey, MJ Smyth
Current medicinal chemistry, 2004•ingentaconnect.comα-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand
recognized by a special group of immune T cells, known as invariant NKT cells. γ-GalCer
can powerfully activate invariant NKT cells to produce immunoregulatory cytokines,
including interferon-α and IL-4, and thereby exert a variety of subsequent effects on other
cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-
induced iNKT cell-activation in immune responses to tumors and microbes, and in the …
recognized by a special group of immune T cells, known as invariant NKT cells. γ-GalCer
can powerfully activate invariant NKT cells to produce immunoregulatory cytokines,
including interferon-α and IL-4, and thereby exert a variety of subsequent effects on other
cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-
induced iNKT cell-activation in immune responses to tumors and microbes, and in the …
α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. γ-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-α and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α- GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.
ingentaconnect.com