Frequency of Vα24+ CD161+ natural killer T cells and invariant TCRAV24-AJ18 transcripts in atopic and non-atopic individuals
C Prell, N Konstantopoulos, B Heinzelmann… - Immunobiology, 2003 - Elsevier
Th2 cells play a central role in type I allergies. However, the source of interleukin-4 which
may lead to a Th1/Th2 imbalance is unknown. Vα24+ CD161+ Natural killer T (NKT) cells
secrete high amounts of interleukin-4 and/or interferon-γ and are assumed to participate in
the initiation of Th1/Th2 immune responses. Their contribution to the development of Th2-
dependent type I allergies is controversial. Our objective in this paper was to determine
whether Vα24+ CD161+ NKT cells differ in atopic and non-atopic adults. Venous blood was …
may lead to a Th1/Th2 imbalance is unknown. Vα24+ CD161+ Natural killer T (NKT) cells
secrete high amounts of interleukin-4 and/or interferon-γ and are assumed to participate in
the initiation of Th1/Th2 immune responses. Their contribution to the development of Th2-
dependent type I allergies is controversial. Our objective in this paper was to determine
whether Vα24+ CD161+ NKT cells differ in atopic and non-atopic adults. Venous blood was …