Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function
RM Locksley, P Scott - Immunology today, 1991 - cell.com
Immunology today, 1991•cell.com
It has been a surprise to find that the two distinct subsets of mouse CD4+ T cells identified
from clones cultured in vitro also occur during Leishmania infection. The spectrum of
disease encountered during these infections ranges from successful resolution to fatal
dissemination and in mice these outcomes are accompanied by expansion of TH 1 or TH 2
CD4+ cells, respectively. This review focuses on the mechanisms that cause such disparate
responses to the parasite.
from clones cultured in vitro also occur during Leishmania infection. The spectrum of
disease encountered during these infections ranges from successful resolution to fatal
dissemination and in mice these outcomes are accompanied by expansion of TH 1 or TH 2
CD4+ cells, respectively. This review focuses on the mechanisms that cause such disparate
responses to the parasite.
It has been a surprise to find that the two distinct subsets of mouse CD4+ T cells identified from clones cultured in vitro also occur during Leishmania infection. The spectrum of disease encountered during these infections ranges from successful resolution to fatal dissemination and in mice these outcomes are accompanied by expansion of TH1 or TH2 CD4+ cells, respectively. This review focuses on the mechanisms that cause such disparate responses to the parasite.
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