Factor VIII-related antigen (FVIII-RA)-positive microvessel areas were measured by both
immunohistochemistry and computerized image analysis in patients with active multiple
myeloma (MM), nonactive MM, and monoclonal gammopathies of undetermined
significance (MGUS). A five-to sixfold larger area was found in patients with active MM
compared to the other two groups. Aquaporin I (AQPI)-positive microvessel areas, measured
with the same techniques on adjacent tissue sections, were also increased in active MM …