A molecular basis for bleomycin-induced pulmonary fibrosis
KR Cutroneo, KM Sterling - Chest, 1986 - journal.chestnet.org
Bleomycin is an antineoplastic agent used in the treatment 1 of several malignancies. Its
mechanism of action is not fully understood, although it is known to cause DNA damage and
an inhibition of DNA synthesis. The principal and ratelimiting toxicity of bleomycin is
pulmonary fibrosis. The fibrotic process includes the participation of many lung cell types,
cell-cell interaction, stimulatory and inhibitory factors, immunologic changes as well as
genetic-related susceptibility. 1 Lung fibrosis induced by bleomycin is characterized by …
mechanism of action is not fully understood, although it is known to cause DNA damage and
an inhibition of DNA synthesis. The principal and ratelimiting toxicity of bleomycin is
pulmonary fibrosis. The fibrotic process includes the participation of many lung cell types,
cell-cell interaction, stimulatory and inhibitory factors, immunologic changes as well as
genetic-related susceptibility. 1 Lung fibrosis induced by bleomycin is characterized by …