[HTML][HTML] Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-β1
JT Kim, CK Joo - Journal of Biological Chemistry, 2002 - ASBMB
Transforming growth factor-β (TGF-β) regulates a wide range of physiological and
pathological cellular processes, including cell migration, mesenchymal transition,
extracellular matrix synthesis, and cell death. Cas (Crk-associated substrate, 130 kDa), an
adaptor protein localized at focal adhesions and stress fibers, is also known to have
important functions in cell migration and the induction of immediate-early gene expression.
Here, we report that a rapid and transient tyrosine phosphorylation of Cas is induced by TGF …
pathological cellular processes, including cell migration, mesenchymal transition,
extracellular matrix synthesis, and cell death. Cas (Crk-associated substrate, 130 kDa), an
adaptor protein localized at focal adhesions and stress fibers, is also known to have
important functions in cell migration and the induction of immediate-early gene expression.
Here, we report that a rapid and transient tyrosine phosphorylation of Cas is induced by TGF …