[HTML][HTML] Interdependent SMAD and JNK signaling in transforming growth factor-β-mediated transcription

ME Engel, MA McDonnell, BK Law… - Journal of Biological …, 1999 - ASBMB
SMAD and JNK cascades are essential components of the transforming growth factor-β
(TGF-β) signaling machinery and are implicated in common transcriptional responses.
However, the relationship of these pathways to one another downstream of the TGF-β
receptor complex is unknown. We show that JNK is rapidly activated by TGF-β in a SMAD-
independent manner and phosphorylates Smad3 outside its-SSXS motif. Smad3
phosphorylation by JNK facilitates both its activation by the TGF-β receptor complex and its …