Role of transforming growth factor β in human disease

GC Blobe, WP Schiemann… - New England Journal of …, 2000 - Mass Medical Soc
New England Journal of Medicine, 2000Mass Medical Soc
In human tissues, normal homeostasis requires intricately balanced interactions between
cells and the network of secreted proteins known as the extracellular matrix. These
cooperative interactions involve numerous cytokines acting through specific cell-surface
receptors. When the balance between the cells and the extracellular matrix is perturbed,
disease can result. This is clearly evident in the interactions mediated by the cytokine
transforming growth factor β (TGF-β). TGF-β is a member of a family of dimeric polypeptide …
In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix. These cooperative interactions involve numerous cytokines acting through specific cell-surface receptors. When the balance between the cells and the extracellular matrix is perturbed, disease can result. This is clearly evident in the interactions mediated by the cytokine transforming growth factor β (TGF-β).
TGF-β is a member of a family of dimeric polypeptide growth factors that includes bone morphogenic proteins and activins. All of these growth factors share a cluster of conserved cysteine residues that form a common cysteine . . .
The New England Journal Of Medicine