Virus-induced autoimmunity: epitope spreading to myelin autoepitopes in Theiler's virus infection of the central nervous system
SD Miller, Y Katz-Levy, KL Neville… - Advances in virus …, 2001 - Elsevier
Epidemiological studies indicate that host immunogenetics and history of infection,
particularly by viruses, may be necessary cofactor for the induction of a variety of
autoimmune diseases. To date, however, there is no clear-cut evidence, either in
experimental animal models or in human autoimmune disease, that supports either
molecular mimicry (Wucherpfennig and Strominger, 1995; Fujinami and Oldstone, 1985) or
a role for superantigens (Scherer et al., 1993) in the initiation of T cell-mediated …
particularly by viruses, may be necessary cofactor for the induction of a variety of
autoimmune diseases. To date, however, there is no clear-cut evidence, either in
experimental animal models or in human autoimmune disease, that supports either
molecular mimicry (Wucherpfennig and Strominger, 1995; Fujinami and Oldstone, 1985) or
a role for superantigens (Scherer et al., 1993) in the initiation of T cell-mediated …