Assignment ofEtfdh, Etfb, andEtfato Chromosomes 3, 7, and 13: The Mouse Homologs of Genes Responsible for Glutaric Acidemia Type II in Human
RA White, LL Dowler, SV Angeloni, DM Koeller - Genomics, 1996 - Elsevier
RA White, LL Dowler, SV Angeloni, DM Koeller
Genomics, 1996•ElsevierElectron transfer flavoprotein (composed of α and β subunits) is an obligatory electron
acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons
accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial
respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or
ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in
its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We …
acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons
accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial
respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or
ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in
its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We …
Electron transfer flavoprotein (composed of α and β subunits) is an obligatory electron acceptor for several dehydrogenases and is located in the mitochondrial matrix. Electrons accepted by electron transfer flavoprotein (ETF) are transferred to the main mitochondrial respiratory chain by way of ETF dehydrogenase (ETFDH). In humans, deficiency of ETF or ETFDH leads to glutaric acidemia type II, an inherited metabolic disorder that can be fatal in its neonatal form and is characterized by severe hypoketotic hypoglycemia and acidosis. We used cDNA probes for theEtfdh, Etfb,andEtfagenes to determine localization of these mouse genes to chromosomes 3, 7, and 13.
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