Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics
Peroxynitrite is an oxidant generated under inflammatory conditions, acting in defense
against invading microorganisms. There is a need for protection of the organism from
damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a
high second-order reaction rate constant (approx. 2× 106 M− 1 s− 1), which makes them
candidates for efficient protection. This applies also for selenium in proteins, occurring as
selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin …
against invading microorganisms. There is a need for protection of the organism from
damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a
high second-order reaction rate constant (approx. 2× 106 M− 1 s− 1), which makes them
candidates for efficient protection. This applies also for selenium in proteins, occurring as
selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin …
Peroxynitrite is an oxidant generated under inflammatory conditions, acting in defense against invading microorganisms. There is a need for protection of the organism from damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a high second-order reaction rate constant (approx. 2 × 106 M−1 s−1), which makes them candidates for efficient protection. This applies also for selenium in proteins, occurring as selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin reductase, and selenoprotein P have been shown to play a potential role in protection against peroxynitrite. Tellurium-containing compounds also react with peroxynitrite.
Elsevier