[HTML][HTML] BAD enables ceramide to signal apoptosis via Ras and Raf-1
S Basu, S Bayoumy, Y Zhang, J Lozano… - Journal of Biological …, 1998 - ASBMB
Prior investigations document that proliferative signaling cascades, under some
circumstances, initiate apoptosis, although mechanisms that dictate the final outcome are
largely unknown. In COS-7 cells, ceramide signals Raf-1 activation through Ras (Zhang, Y.,
Yao, B., Delikat, S., Bayoumy, S., Lin, XH, Basu, S., McGinley, M., Chan-Hui, PY, Lichenstein,
H., and Kolesnick, R.(1997) Cell 89, 63–72), but not apoptosis. However, expression of
small amounts of the pro-apoptotic Bcl-2 family member, BAD, conferred ceramide-induced …
circumstances, initiate apoptosis, although mechanisms that dictate the final outcome are
largely unknown. In COS-7 cells, ceramide signals Raf-1 activation through Ras (Zhang, Y.,
Yao, B., Delikat, S., Bayoumy, S., Lin, XH, Basu, S., McGinley, M., Chan-Hui, PY, Lichenstein,
H., and Kolesnick, R.(1997) Cell 89, 63–72), but not apoptosis. However, expression of
small amounts of the pro-apoptotic Bcl-2 family member, BAD, conferred ceramide-induced …